WebConcurrent nuclear ERG and MYC protein overexpression is common in prostate cancer and defines a subset of locally advanced tumors. Recent data indicates that BET bromodomain proteins regulate ERG gene fusion and MYC gene expression in prostate cancer, suggesting possible synergistic targeted therapeutics in ERG-positive/MYC high tumors. WebApr 10, 2024 · Conclusion: Our study provided a safety targeted delivery strategy, and enhanced the therapeutic efficiency of SDT/PTT synergistic treatment. This study designed an oxygen-deficient TiO2-x coated with glutamine layer for targeted delivery, as well as the enhanced separation of electrons and holes following the joint application of …
Gemcitabine–camptothecin conjugates: a hybrid prodrug for …
WebSep 12, 2024 · Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced … WebThese receptors are strongly expressed in brain, lung, breast, colon, ovarian cancers and can be served as physiological target ligands for therapeutic drug delivery. 8–12 Because folic acid is a stable and generally poorly immunogenic chemical with a high affinity toward the folate receptor, it is widely used as a versatile moiety on the surface of drug carriers to … how to write off unpaid invoices quickbooks
Nucleus-selective codelivery of proteins and drugs for synergistic ...
WebSep 18, 2024 · Sugars containing cationic polymers are potential carriers for in vitro and in vivo nucleic acid delivery. Monosaccharides such as glucose and galactose have been chemically conjugated to various materials of synergistic poly-lysine dendrimer systems for efficient and biocompatible delivery of short interfering RNA (siRNA). The synergistic … WebThe integrated nanoplatform showed a superior synergistic effect in vitro and possessed precise spatial delivery to HepG2 cells with the dual-targeting nanocarrier. Intriguingly, a … WebSep 14, 2024 · A 22-year-old woman had significant weight gain after being on two atypical antipsychotics, an antiepileptic, and an antidepressant for 12 months, with her weight increasing from 70 kg to 160 kg, or by 90 kg, over 16 months. This case report examines the possible synergistic effects of psychotropics, particularly two atypical antipsychotics, … orisha calendar 2021